Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling
Archives of Maternal and Child Health, 1(1), 2026, amch002, https://doi.org/10.63946/amch/18464
Publication date: Apr 23, 2026
ABSTRACT
Cervical cancer remains a major public health concern in Kazakhstan despite ongoing prevention efforts. Although incidence has declined in many high-income countries due to effective screening and human papillomavirus vaccination programs, Kazakhstan continues to report relatively high incidence and still considerable mortality rates compared with many developed regions. This narrative review summarizes the current epidemiological trends, screening practices, and prevention strategies for cervical cancer in Kazakhstan. National screening programs based on cytology have been implemented since 2008 and have improved early detection; however, screening coverage remains below the World Health Organization target of 70%, with participation particularly low in rural areas due to limited awareness, access barriers, and logistical challenges. The prevalence of human papillomavirus infection among women in Kazakhstan is relatively high, with high-risk types contributing significantly to disease burden. The reintroduction of the national HPV vaccination program targeting adolescents represents an important step toward long-term cervical cancer prevention. In addition, emerging screening approaches such as HPV self-sampling offer promising opportunities to increase screening uptake, especially among under-screened populations. Integrating vaccination programs with innovative and accessible screening strategies, alongside improved awareness, follow-up systems, and health system support, could significantly enhance cervical cancer prevention efforts. Strengthening these interventions will be essential for Kazakhstan to reduce cervical cancer burden and move toward achieving the World Health Organization goal of cervical cancer elimination.
KEYWORDS
Uterine Cervical Neoplasms Papillomavirus Infections Mass Screening Papillomavirus Vaccines Papanicolaou Test
CITATION (Vancouver)
Rakhat A. Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling. Archives of Maternal and Child Health. 2026;1(1):amch002. https://doi.org/10.63946/amch/18464
APA
Rakhat, A. (2026). Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling. Archives of Maternal and Child Health, 1(1), amch002. https://doi.org/10.63946/amch/18464
Harvard
Rakhat, A. (2026). Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling. Archives of Maternal and Child Health, 1(1), amch002. https://doi.org/10.63946/amch/18464
AMA
Rakhat A. Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling. Archives of Maternal and Child Health. 2026;1(1), amch002. https://doi.org/10.63946/amch/18464
Chicago
Rakhat, Altynshash. "Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling". Archives of Maternal and Child Health 2026 1 no. 1 (2026): amch002. https://doi.org/10.63946/amch/18464
MLA
Rakhat, Altynshash "Cervical Cancer Screening in Kazakhstan: Progress, Gaps, and the Promise of HPV Self-Sampling". Archives of Maternal and Child Health, vol. 1, no. 1, 2026, amch002. https://doi.org/10.63946/amch/18464
SUPPLEMENTARY FILES
REFERENCES
- World Health Organization. Cervical cancer [Internet]. Geneva: World Health Organization; 2025 Dec 2. Available from: https://www.who.int/news-room/fact-sheets/detail/cervical-cancer
- Hamid MKI, Hasneen S, Lima AK, Shawon SRR, Shahriar M, Anjum R. Cervical cancer trends, HPV vaccine utilization, and screening in low- and lower-middle-income countries: an updated review. Ther Adv Vaccines Immunother. 2025;13:25151355251356646. doi:10.1177/25151355251356646
- Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169–182. doi:10.1016/s0140-6736(18)32470-x
- Hull R, Mbele M, Makhafola T, Hicks C, Wang SM, Reis RM, et al. Cervical cancer in low- and middle-income countries. Oncol Lett. 2020;20(3):2058–2074. doi:10.3892/ol.2020.11754
- International Agency for Research on Cancer. GLOBOCAN: Cancer Tomorrow [Internet]. Lyon: IARC; [cited 2026 Apr 20]. Available from: https://gco.iarc.fr/tomorrow/en/dataviz/tables?mode=cancer&group_populations=1&years=2030
- Juntamongkol T, Siranart N, Phutinart S, Chitwarodom C, Kassels T, Tachapornsin P, et al. Disparities in Human Papillomavirus vaccination and cervical cancer prevention and screening strategies: a meta-analysis. Asian Pac J Cancer Prev. 2025;26(11):3997–4008. doi:10.31557/apjcp.2025.26.11.3997
- Petersen Z, Jaca A, Ginindza TG, Maseko G, Takatshana S, Ndlovu P, et al. Barriers to uptake of cervical cancer screening services in low-and-middle-income countries: a systematic review. BMC Womens Health. 2022;22(1):486. doi:10.1186/s12905-022-02043-y
- Izbagambetov NA, Kaidarova DR, Bolatbekova RO, et al. Cervical cancer incidence and mortality in Almaty in 2005–2022. Oncol Radiol Kazakhstan. 2023;2(68):9–14. doi:10.52532/2663-4864-2023-2-68-9-14
- Zhetpisbayeva I, Rommel A, Kassymbekova F, Semenova Y, Sarmuldayeva S, Giniyat A, et al. Cervical cancer trend in the Republic of Kazakhstan and attitudes towards cervical cancer screening in urban and rural areas. Sci Rep. 2024;14:13731. doi:10.1038/s41598-024-64566-8
- Utegenova A, Kassymova G, Fakhradiyev I. Experience of implementing digital telemedicine technologies to improve access to cervical cancer screening in rural areas of the Republic of Kazakhstan. Georgian Med News. 2025;(350): [page numbers if available].
- Arbyn M, Smith SB, Temin S, Sultana F, Castle P. Detecting cervical precancer and reaching underscreened women by using HPV testing on self-samples: updated meta-analyses. BMJ. 2018;363:k4823. doi:10.1136/bmj.k4823
- Kamath Mulki A, Withers M. Human papilloma virus self-sampling performance in low- and middle-income countries. BMC Womens Health. 2021;21(1):12. doi:10.1186/s12905-020-01158-4
- Amirbekova K. Cervical cancer screening using the self-sampling method among Kazakhstani women: a pilot validation study. Astana Med J. 2025;125(6). doi:10.54500/2790-1203-2025-6-125-amj004
- Ginsburg O, Bray F, Coleman MP, Vanderpuye V, Eniu A, Kotha SR, et al. The global burden of women's cancers: a grand challenge in global health. Lancet. 2017;389(10071):847–860. doi:10.1016/S0140-6736(16)31392-7
- Shalgumbayeva G, Zhabagina A, Kuanysheva A, Sandybayev MR, Faizova R, Belikhina T, et al. Incidence and mortality of cervical cancer in the Republic of Kazakhstan: 2007–2016. Iran J Public Health. 2020;49(6):1120–1128. doi:10.18502/ijph.v49i6.3364
- Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–263. doi:10.3322/caac.21834
- Son Y, Hong S, Jang W, Kim S, Lee H, Lee S, et al. Global, regional, and national burden of cervical cancer in 2022 and projections to 2050: a population-based analysis of GLOBOCAN. Int J Gynecol Cancer. 2026;36(1):102751. doi:10.1016/j.ijgc.2025.102751
- Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191–e203. doi:10.1016/s2214-109x(19)30482-6
- Balmagambetova SK, Tinelli A, Urazayev ON, Sakieva KZ, Koyshybaev AK, Zholmukhamedova DA, et al. HPV types distribution in general female population and in women diagnosed with cervical cancer across Western Kazakhstan. Asian Pac J Cancer Prev. 2019;20(4):1089–1096. doi:10.31557/apjcp.2019.20.4.1089
- Niyazmetova L, Aimagambetova G, Stambekova N, Abugalieva Z, Seksembayeva K, Ali S, et al. Application of molecular genotyping to determine prevalence of HPV strains in Pap smears of Kazakhstan women. Int J Infect Dis. 2017;54:85–88. doi:10.1016/j.ijid.2016.11.410
- Babi A, Issa T, Issanov A, Akilzhanova A, Nurgaliyeva K, Abugalieva Z, et al. Prevalence of high-risk human papillomavirus infection among Kazakhstani women attending gynecological outpatient clinics. Int J Infect Dis. 2021;109:8–16. doi:10.1016/j.ijid.2021.06.006
- Ukybassova T, Aimagambetova G, Kongrtay K, Kassymbek K, Terzic M, Makhambetova S, et al. Correlation of HPV status with colposcopy and cervical biopsy results among non-vaccinated women: findings from a tertiary care hospital in Kazakhstan. Vaccines (Basel). 2025;13(11):1151. doi:10.3390/vaccines13111151
- Aimagambetova G, Chan CK, Ukybassova T, Imankulova B, Balykov A, Kongrtay K, et al. Cervical cancer screening and prevention in Kazakhstan and Central Asia. J Med Screen. 2021;28(1):48–50. doi:10.1177/0969141320902482
- Simms KT, Steinberg J, Caruana M, Smith MA, Lew J-B, Soerjomataram I, et al. Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries, 2020–99: a modelling study. Lancet Oncol. 2019;20(3):394–407. doi:10.1016/S1470-2045(18)30836-2
- Ablimitova F, Nabirova D, Gazezova S, Smagul M, Kuatbaeva A, Yesmagambetova A, et al. Human papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan – 2023. Hum Vaccin Immunother. 2026;22(1): [article number if available]. doi:10.1080/21645515.2026.1234567 (Note: DOI not provided in original; placeholder shown)
- Kassymbekova F, Rommel A, Kaidarova D, Auyezova A, Nukusheva S, Dunenova G, et al. Developing HPV vaccination communication strategies: assessing knowledge, attitudes, and barriers among healthcare professionals in Kazakhstan. Vaccines (Basel). 2024;12(11):1225. doi:10.3390/vaccines12111225
- Brisson M, Drolet M. Global elimination of cervical cancer as a public health problem. Lancet Oncol. 2019;20(3):319–321. doi:10.1016/s1470-2045(19)30072-5
- Gusmanov A, Yeskendir A, BRIF Research Group. Behaviour insights research on drivers influencing immunization-related behaviours in Kazakhstan. Astana: UNICEF Kazakhstan; 2023 Apr. Available from: https://www.unicef.org/kazakhstan/media/10156/file/Behaviour%20Insights%20Research%20on%20Drivers%20Influencing%20Immunization-Related%20Behaviours%20in%20Kazakhstan.pdf
- Drolet M, Bénard E, Pérez N, Brisson M; HPV Vaccination Impact Study Group. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. Lancet. 2019;394(10197):497–509. doi:10.1016/S0140-6736(19)30298-3
- World Health Organization. Protecting a generation: Kazakhstan's commitment to HPV vaccination. Geneva: World Health Organization; 2024 Jan 19. Available from: https://www.who.int/europe/news/item/19-01-2024-protecting-a-generation--kazakhstan-s-commitment-to-hpv-vaccination
- Aimagambetova G, Azizan A. Epidemiology of HPV infection and HPV-related cancers in Kazakhstan: a review. Asian Pac J Cancer Prev. 2018;19(5):1175–1180. doi:10.22034/APJCP.2018.19.5.1175
- Bruni L, Albero G, Serrano B, Mena M, Collado JJ, Gómez D, et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human papillomavirus and related diseases in the world. Summary report. 2023 Mar 10 [cited 2024 Jan 9]. Available from: https://www.hpvcentre.net
- Imankulova B, Babi A, Issa T, Zhumakanova Z, Knaub L, Yerzhankyzy A, et al. Prevalence of precancerous cervical lesions among nonvaccinated Kazakhstani women: the National Tertiary Care Hospital screening data (2018). Healthcare (Basel). 2023;11(2):235. doi:10.3390/healthcare11020235
- World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem. Geneva: World Health Organization; 2020. Available from: https://www.who.int/publications-detail-redirect/9789240014107
- Rakhat A, Marat A, Sakhipova G, Sakko Y, Aimagambetova G. Self-sampling modality for cervical cancer screening: overview of the diagnostic approaches and sampling devices. Sci. 2026;8(1):5. doi:10.3390/sci8010005
- Serrano B, Ibáñez R, Robles C, Peremiquel-Trillas P, de Sanjosé S, Bruni L. Worldwide use of HPV self-sampling for cervical cancer screening. Prev Med. 2022;154:106900. doi:10.1016/j.ypmed.2021.106900
- Nishimura H, Yeh PT, Oguntade H, Kennedy CE, Narasimhan M. HPV self-sampling for cervical cancer screening: a systematic review of values and preferences. BMJ Glob Health. 2021;6(5):e003743. doi:10.1136/bmjgh-2020-003743
- Boyard J, Caille A, Brunet-Houdard S, Sengchanh-Vidal S, Giraudeau B, Marret H, et al. A home-mailed versus general practitioner-delivered vaginal self-sampling kit for cervical cancer screening: a cluster randomized controlled trial with a cost-effectiveness analysis. J Womens Health (Larchmt). 2022;31(8):1123–1133. doi:10.1089/jwh.2021.0597
- Perkins RB, Wentzensen N, Guido RS, Schiffman M. Cervical cancer screening. JAMA. 2023;330(6):547. doi:10.1001/jama.2023.13174
- Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, et al. 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis. 2020;24(2):102–131. doi:10.1097/LGT.0000000000000525
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