Case Report
May 08, 2026
4
2
Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report
Archives of Maternal and Child Health, 1(1), 2026, amch003, https://doi.org/10.63946/amch/18538
Publication date: May 08, 2026
ABSTRACT
Central precocious puberty is an uncommon but important paediatrics endocrine condition that requires timely recognition and evaluation to prevent adverse auxological and psychosocial outcomes. We present the case of a 6-year-old girl with a 10-month history of progressive breast enlargement and pubic and axillary hair development. Clinical examination revealed markedly advanced secondary sexual characteristics, consistent with Tanner stage IV maturation. Endocrine evaluation demonstrated pubertal-range gonadotropin concentrations, and dynamic testing with a gonadotropin-releasing hormone agonist showed a pubertal luteinizing hormone response, supporting activation of the hypothalamic-pituitary-gonadal axis. Bone age assessment demonstrated advancement beyond chronological age, while pelvic ultrasonography showed pubertal uterine morphology. Brain magnetic resonance imaging revealed no hypothalamic-pituitary or other intracranial lesion. Following clinical, biochemical, radiological, and imaging assessment, a diagnosis of idiopathic central precocious puberty was made. The patient’s parents were counselled on the diagnosis, treatment options, expected benefits, and need for follow-up, and treatment with a gonadotropin-releasing hormone analogue was commenced. This case underscores the importance of a structured approach to children presenting with early progressive pubertal development, including careful clinical assessment, bone age evaluation, endocrine testing, pelvic imaging, and neuroimaging where indicated.
KEYWORDS
Central Precocious Puberty Idiopathic Precocious Puberty GnRH Agonist Stimulation Test Bone Age Tanner Stage IV Nigerian Child
CITATION (Vancouver)
Nwogu CM, Omisakin SI, Ugwu AO, Abati AO, Ejiole GN, Iniso J, et al. Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report. Archives of Maternal and Child Health. 2026;1(1):amch003. https://doi.org/10.63946/amch/18538
APA
Nwogu, C. M., Omisakin, S. I., Ugwu, A. O., Abati, A. O., Ejiole, G. N., Iniso, J., & Giwa-Osagie, O. F. (2026). Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report. Archives of Maternal and Child Health, 1(1), amch003. https://doi.org/10.63946/amch/18538
Harvard
Nwogu, C. M., Omisakin, S. I., Ugwu, A. O., Abati, A. O., Ejiole, G. N., Iniso, J., and Giwa-Osagie, O. F. (2026). Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report. Archives of Maternal and Child Health, 1(1), amch003. https://doi.org/10.63946/amch/18538
AMA
Nwogu CM, Omisakin SI, Ugwu AO, et al. Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report. Archives of Maternal and Child Health. 2026;1(1), amch003. https://doi.org/10.63946/amch/18538
Chicago
Nwogu, Chidinma M., Sunday I. Omisakin, Aloy Okechukwu Ugwu, Abraham O. Abati, George N. Ejiole, James Iniso, and Osato F. Giwa-Osagie. "Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report". Archives of Maternal and Child Health 2026 1 no. 1 (2026): amch003. https://doi.org/10.63946/amch/18538
MLA
Nwogu, Chidinma M. et al. "Idiopathic Central Precocious Puberty in a 6-Year-Old Girl with Advanced Secondary Sexual Characteristics: A Case Report". Archives of Maternal and Child Health, vol. 1, no. 1, 2026, amch003. https://doi.org/10.63946/amch/18538
REFERENCES
- Yoon DY, Kim JH. An 11-month-old girl with central precocious puberty caused by hypothalamic hamartoma. Ann Pediatr Endocrinol Metab. 2016;21(4):235-239. doi:10.6065/apem.2016.21.4.235
- Dallos-Lara MF, Mendoza V, Rojas A. Precocious puberty due to congenital adrenal hyperplasia: case report. Rev Fac Med. 2020;68(1). doi:10.15446/revfacmed.v68n1.72674
- Joo EY, Yoo MJ, Kim SJ, Jang W, Lee JE. Case report: development of central precocious puberty in a girl with late-diagnosed simple virilizing congenital adrenal hyperplasia complicated with Williams syndrome. Front Endocrinol (Lausanne). 2024;15:1352552. doi:10.3389/fendo.2024.1352552
- Castro C, Machado Morais J, Correia AL, Espada F. Hypothalamic hamartoma: a cause of precocious puberty. BMJ Case Rep. 2023;16(3):e254429. Published 2023 Mar 24. doi:10.1136/bcr-2022-254429
- Suh J, Choi Y, Oh JS, et al. Management of Central Precocious Puberty in Children with Hypothalamic Hamartoma. Children (Basel). 2021;8(8):711. Published 2021 Aug 18. doi:10.3390/children8080711
- Helyaich A, Elqadiry R, El Fakiri K, Rada N, Draiss G, Bouskraoui M. Case Report of Central Precocious Puberty in a Female: Role of Environmental Pollutants? Clin Med Insights Case Rep. 2020;13:1179547620933585. Published 2020 Jul 9. doi:10.1177/1179547620933585
- Oluwayemi IO, Afolabi AA, Adeniji EO, Ayeni TO. Precocious puberty in a 24 month old Nigerian girl. Niger J Paediatr. 2024;47(4):358-360. doi:10.4314/njp.v47i4.10
- Oni T, Adekoya A, Elizabeth G, Nwadiokwu J, Okebalama V, Anifowose O. Pseudo-precocious puberty secondary to juvenile granulosa cell tumour in a 30-month-old female toddler: a case report. Babcock Univ Med J. 2024;7(2):108-113. doi:10.38029/babcockuniv.med.j.v7i2.560
LICENSE
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.